
Activated Silk® 33B-α
A natural protein regulator for moisture-rich skin, reduction in TEWL and a healthier, more youthful appearance. This peptide bioactively turns the skin on, promoting the natural production of claudin-1, a vital skin health protein that binds skin cells together, creating a healthier barrier that keeps moisture in and irritants out.
Size
Activated Silk® 33B - α
Nothing boosts the barrier like the barrier itself.
- A water soluble peptide that works in places ceramides and petrolatum cannot
- Supports the natural production of claudin, boosting the skin barrier’s ability to maintain tight junctions between cells for hydrated, happier, healthier‑looking skin
- Prevents signs of irritation and premature aging such as fine lines and wrinkles
Introducing Activated Silk® 33B-α — the bioactive peptide that supports healthier, younger looking skin for all skin types, and is even proven effective against symptoms associated with eczema-prone skin.
Nature always beats petrochemicals. And Activated Silk® 33B-α is water soluble, so you can use it in formulations where synthetic ingredients like petrolatum and ceramides cannot be used.
While those synthetic ingredients coat the skin to mask symptoms, Activated Silk® 33B-α turns the skin on, supporting the natural production of claudin to boost the barrier.
And the peptides stay on the skin after rinsing, so Activated Silk® 33B-α can effectively be delivered in rinse-off products like soaps and cleansers.
94% of people who used it report younger, healthier looking skin.04 But try a free sample for your formulations and see for yourself.

Activated Silk® 33B-α Claims
Performance04
- Clinically proven to support skin health
- Reduces signs of aging
- Reduces the appearance of fine lines and wrinkles
- Improves the appearance of skin firmness
- Reduces the appearance of redness in as little as 7 days
- Significantly reduces TEWL in as little as 7 days
- Improves skin hydration in as little as 7 days
- Improves skin moisture barrier
- Improves skin barrier integrity
Footnotes
01The manufacturing of Activated Silk® technology contributes to achieving 14/17 U.N. Sustainable Development Goals. For more information, visit sdgs.un.org/goals
02Compared to petrochemical ingredients.
03Activated Silk® peptides are naturally-derived. For more information on NATRUE approvals, see www.natrue.org
04Based on a clinical study of 32 subjects using 2% Activated Silk® 33B-α in a leave-on product over a 28-day use period.
05Based on a clinical study of 19 subjects using 0.5% Activated Silk® 27P-α over a 28-day use period.
06Based on a clinical study of 18 subjects using 0.5% Activated Silk® 8A-α over a 28-day use period.
07Based on a clinical study of 17 subjects using 0.5% Activated Silk® KDF-β over a 2-day use period.
08Not manufactured with PEG or palm ingredients.
09Not manufactured with silicone ingredients.